It is very important to note that the long term side effects of Melatonin are still unknown. There is a need for more research to know what are the side effects of melatonin if it is used for a very long time. 2 Melatonin as an Antioxidant. 8211; Melatonin also plays a role in the endocrine-reproductive system and it reduces the circulation of Leuteniz.

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